SAMMI - small animal MRI/MRS instrument at UGA

		SAMMI - Small Animal MRI/MRS Instrument

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The initial results from the first clinical trial, with hyperpolarized [1- 13 C]pyruvate in prostate cancer, show great promise (http://news.ucsf.edu/releases/new-prostate-cancer-imaging-shows-real-time-tumor-metabolism/, accessed November 2010).
Hyperpolariation

The greatest hurdle to use of (13C/15N) MRS in preclinical and clincal is due to its limited sensitivities. Hyperpolarization techniques has eliminated these hurdles and enhances the sensitivity of labelled substrates to several folds. This has tremendous potential in in vivo. Lot of work has been going on for last 10 years in these area. We are also in the process of developing and impelmenting invivo based 13C and 15N techniques in mice and rats.
Given below is the link for more recent developments in Hyperpolarization.

SAMMI - Small Animal MRI/MRS Instrument